I've been working in Raiser's Edge for a very long time, but have been onboarding a new customer this summer and they are asking a lot of questions as they learn. They really stumbled over the idea that the queries needed for email needed to be saved as lists. I've just always known this to be the case, and it was the same in OLX, but I never stopped to think about why.
At some stage, anyone who is marked as "Requests no email" is removed, as well as any email addresses that are marked as DNC, but I believe that takes place after the list is uploaded as the audience for an email.
Does anyone know the answer?